2025 ASCRS临床实践指南：阑尾肿瘤的管理

指南消化内科· 其他消化疾病 · 2025

Pathologic lesion

Criteria

Acellular mucin

Mucin within peritoneal cavity without neoplastic epithelial cells

Low-grade mucinous carcinoma peritonei (DPAM)

Epithelial component typically scanty

Minimal cytological atypia

Strips, gland-like structures, or small cell clusters

High-grade mucinous carcinoma peritonei (PMCA)

* Relatively more cellular

Cribriform growth pattern

* High-grade cytological atypia

Numerous mitoses

High-grade mucinous carcinoma peritonei with signet-rings cells (PMCA-S)

* Any lesion with a sign-ring cell component, that is, round cells with intracytoplasmic mucin pushing nucleus against cell membrane

Adapted from Carr et al.$^{11}$

DPAM = disseminated peritoneal adenomucinosis; PMCA = peritoneal mucinous carcinomatosis; PMCA-S = peritoneal mucinous carcinomatosis with signet-ring cells.

size, depth of invasion, or degree of differentiation. Other rare nonepithelial appendiceal neoplasms include GI stromal tumors, lymphomas, and neural proliferations, which are outside the scope of this guideline.

estimates of effect. Evidence from randomized controlled trials start as high certainty, and evidence derived from observational studies start as low certainty. For each outcome, the evidence is graded as high, moderate, low, or very low (Table 2). The evidence can be rated down for risk of bias, inconsistency, indirectness, imprecision, and publication bias. The certainty of evidence originating from observational studies can be rated up when there is a large magnitude of effect or dose-response relationship. As per GRADE methodology, recommendations are labeled as “strong” or “conditional.” All statements with strength of GRADE recommendations are stated in Table 3. Table 4 summarizes the new, updated, and excluded recommended clinical practice guidelines compared with the 2019 guidelines. Recommendations formulated by the subcommittee were reviewed by the entire

METHODOLOGY

These guidelines were built on the previous clinical practice guidelines for the management of appendiceal neoplasms published in 2019.$^{22}$ An organized search of MEDLINE, PubMed, Embase, and the Cochrane Database of Systematic Reviews was performed from December 1, 2018, through February 6, 2025. Pertinent inclusion criteria were English language article and adult human patients, and both current and archaic terminology for appendiceal neoplasms were included as follows: (appendiceal, appendix, appendicular) AND (adenocarcinoma, carcinoma, mucinous, pseudomyxoma, signet, cystadenoma, tumor, tumour, neoplasm, cancer). These groups were combined with various treatment modalities to include surgery and chemotherapy. Directed searches using embedded references from primary articles were performed in selected circumstances. Of 1261 records screened, 347 were evaluated for their level of evidence, favoring clinical trials, meta-analyses/systematic reviews, comparative studies, and large registry retrospective studies over single institutional series, retrospective reviews, and peer-reviewed observational studies. Additional references identified through embedded references and other sources as well as practice guidelines and consensus statements from relevant societies were also reviewed. A final list of 72 sources was evaluated for methodological quality, the evidence base was examined, and a treatment guideline was formulated by the subcommittee for this guideline (Fig. 1).

Certainty of Evidence

The final grade of recommendation and level of evidence for each statement were determined using the Grades of Recommendation, Assessment, Development, and Evaluation (GRADE) methodology system. The certainty of evidence reflects the extent of our confidence in the

from observational studies can be rated up when there is a large magnitude of effect or dose-response relationship. As per GRADE methodology, recommendations are labeled as “strong” or “conditional.” All statements with strength of GRADE recommendations are stated

In Table 3. Table 4 summarizes the new, updated, and excluded recommended clinical practice guidelines compared with the 2019 guidelines. Recommendations formulated by the subcommittee were reviewed by the entire

mulated by the subcommittee were reviewed by the entire

Clinical Practice Guidelines Committee. The submission was then approved by the ASCRS Executive Council and peer-reviewed in Diseases of the Colon & Rectum. In general, each ASCRS Clinical Practice Guideline is updated approximately every 5 years. No funding was received for preparing this guideline, and the authors have declared no competing interests related to this material. This guideline conforms to the Appraisal of Guidelines for Research and Evaluation checklist.$^{23}$

GENERAL CONSIDERATIONS

1. Colonoscopy should be performed in patients with confirmed or suspected appendiceal neoplasms. Strength of recommendation: strong recommendation based on low-quality evidence.

Patients with appendice neoplasms have been reported to be at an increased risk of synchronous colonic lesions compared with the general population. Population-based studies have reported that 13% to 42% of patients with primary appendice lesions have concurrent colorectal neoplasia.$^{7,8,24,25}$ In a population-based study from the Netherlands from 1995 to 2005, which included 1482 patients with an appendice epithelial neoplasm, 193 patients (13%) had an

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![graph TD\n A1[Primary search terms: (appendical OR appendix OR appendicular) AND (adenocarcinoma OR carcinoma OR mucinous OR pseudoxyoma OR signet OR cystadenoma OR tumour OR tumour OR neoplasia OR cancer) AND (therapy OR treatment OR chemotherapy OR immunotherapy OR antineoplastic OR surgery OR oncological procedure OR diagnosis) Databases: Cochrane, MEDLINE, PubMed, Embase. Years covered: April 30, 2019-December 2, 2024 Language: English] --> A2[Total records(n = 1419) Total records after duplicates removed(n = 1257)]\n A2 --> A3[Additional records identified through other sources(n = 4)]\n A2 --> A4[Records screened(n = 1261)]\n A3 --> A4\n A4 --> A5[Articles and abstracts assessed for eligibility(n = 347)]\n A4 --> A6[Records excluded(n = 914) Irrelevant/unrelated(n = 541) Case reports(n = 202) Commentary/letters/errata(n = 103) Pediatric patients(n = 51) Duplicate publications(n = 17)]\n A5 --> A7[Full-text articles excluded(n = 275)]\n A5 --> A8[Studies referenced in CPG assignments(n = 72)]\n](1/parseimages/figure73e82f5f55f24b6381882d48cd0f12a4_0_2.png) |Evaluation|Description| |---|---| |Recommendation|| |Strong|Most individuals should receive the intervention. Formal decision aids are not likely to be needed to help individuals make decisions consistent with their values and preferences| |Conditional|Different choices will be appropriate for individual patients consistent with their values and preferences. Use shared decision-making. Decision aids may be useful in helping patients make decisions consistent with their individual risks, values, and preferences| |GRADE certainty ranking|| |High|The authors are confident that the true effect is similar to the estimated effect| |Moderate|The authors believe that the true effect is probably close to the estimated effect| |Low|The true effect might be markedly different from the estimated effect| |Very low|The true effect is probably markedly different from the estimated effect|

GRADE = Grading of Recommendations, Assessments, Development, and Evaluation.

incidental colonic adenoma (n = 37) or adenocarcinoma (n = 156).$^{7}$ In this study, the primary pathology of the appendiceal neoplasms was reported as mucinous cystadenoma (32%), LAMN (31%), and nonmucinous adenoma (26%). Of note, the majority (82%) of colonic adenocarcinomas discovered were right sided. Given the risk of synchronous colonic lesions, patients with a suspected appendiceal neoplasm on

imaging should undergo a preoperative colonoscopy before formal resection of the appendiceal neoplasm.

2. Appendectomy should be performed if a grossly abnormal appendix is encountered during an unrelated abdominal operation. Strength of recommendation: strong recommendation based on low-quality evidence.

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TABLE 3. Summary and strength of GRADE recommendations

||Summary|Recommendation strength|GRADE quality of evidence| |---|---|---|---| |1|Colonoscopy should be performed in patients with confirmed or suspected appendiceal neoplasms|Strong|Low| |2|Appendectomy should be performed if a grossly abnormal appendix is encountered during an unrelated abdominal operation|Strong|Low| |3|Interval appendectomy after complicated appendicitis is typically recommended in adult patients older than 40 y and in those with imaging findings suggestive of a malignant process, given the risk of occult malignancy|Conditional|Low| |4|Preoperative assessment of patients with appendiceal NETs should include physical examination, colos-noscopy, and CT or MRI of the chest, abdomen, and pelvis|Strong|Low| |5|NET-specific imaging should be considered in patients with lesions >2 cm, symptoms of carcinoid syndrome, and findings indeterminate for metastatic disease in other imaging studies|Conditional|Moderate| |6|Biochemical testing should not be routinely performed in patients with appendiceal NETs before treatment, although in the setting of metastatic disease, it may be considered to establish a baseline for future disease monitoring|Strong|Moderate| |7|Extent of surgical resection of appendiceal NETs is determined by tumor size and histologic features|Strong|Low| |8|Surveillance after resection of appendiceal NETs with curative intent should selectively involve physical examination, serial biochemical testing, and imaging of the chest, abdomen, and pelvis using either CT or MRI|Conditional|Low| |9|CEA, CA 19-9, and CA-125 should typically be assessed on the diagnosis of appendiceal epithelial neoplasms and routinely surveyed after resection|Conditional|Low| |10|Cross-sectional imaging with CT or MRI should be obtained at the time of diagnosis in patients with appendiceal epithelial appendiceal epithelina neoplasms and routinely used for postoperative surveillance|Strong|Moderate| |11|Routine peritoneal cytology is not recommended in patients with appendiceal tumors|Conditional|Low| |12|Patients with LAMNs with negative margins and no evidence of perforation or peritoneal involvement|Strong|Moderate| |13|Patients with nonmetastatic adenocarcinoma of the appendix should undergo right hemicolectomy. However, in the setting of peritoneal spread, right hemicolectomy typically does not confer a survival benefit|Strong|Low| |14|Cytoreductive surgery is indicated in select patients with appendiceal neoplasms and evidence of peritoneal involvement|Strong|Moderate| |15|In patients with appendiceal epithelial neoplasms, intraperitoneal chemotherapy after cytoreductive surgery compared to cytoreductive surgery alone may reduce peritoneal disease recurrence, although its impact on overall survival is not established and has been associated with increased costs and toxicity|Strong|Moderate| |16|Systemic chemotherapy may improve survival in patients with metastatic, lymph node positive, HAMNs, and adenocarcinoma with peritoneal metastases. Routine use of systemic chemotherapy for LAMNs or well-differentiated mucinous adenocarcinoma with peritoneal spread is not recommended|Strong|Low| |17|Minimally invasive aerosolized approaches to peritoneal carcinosis require specialized equipment and expertise and have shown acceptable short-term oncologic outcomes, but there is a paucity of long-term data|Conditional|Low|

CA-125 = cancer antigen 125; CA 19-9 = carbohydrate antigen 19-9; GRADE = Grades of Recommendation, Assessment, Development, and Evaluation; HAMN = high-grade appendice neoplasm; LAMN = low-grade appendice neoplasm; NET = traditional neuroendocrine tumor.

During an abdominal or pelvic operation unrelated to appendiceal pathology, an appendectomy is warranted for incidental findings of luminal dilation, serosal irregularity, or mass. Care must be taken to avoid intraoperative perfo-ration and spillage.$^{26-28}$ In most cases, an appendectomy or partial ceectomy is sufficient when an abnormal appen- dix is encountered incidentally. The extent of resection is predominantly based on the involvement of the base of the appendix with the priority of obtaining a grossly negative margin, and care should be taken to avoid rupture, regard- less of the operative approach.$^{29}$ When performing a min-ally invasive approach, surgeons should use a specimen retrieval bag to avoid spilling mucin in the peritoneal cavity or abdominal wall. In traperitoneal mucin found incen- tally may suggest the presence of a mucinous neoplasm

of the GI or gynecologic tracts. In this setting, careful inspection and documentation of the appendix, adnexa in a female patient, and entire extent of peritoneal disease using the peritoneal cancer index (PCI) scoring system (see the following paragraphs for details), including representative biopsies, is warranted. In addition, in the presence of peritoneal disease or when the neoplasm is not confined to the appendix, representative biopsies without appendec-tomy are recommended. Data from multiple retrospective, single-institution studies do not support routine appendec-tomy for a normal-appearing appendix in the setting of an ovarian mucinous neoplasm because the incidence of syn-chronous appendiceal pathology in these cases is low.$^{30-32}$

Although helpful with other GI malignancies and peritoneal implants, the intraoperative frozen section of

GAERTNER ET AL: MANAGEMENT OF APPENDICEAL NEOPLASMS

TABLE 4. What is new in the 2025 ASCRS clinical practice guidelines on the management of appendiceal neoplasms

2025 New recommendations

3. Interval appendectomy after complicated appendicitis is typically recommended in adult patients older than 40 years and in those with imaging findings suggestive of a malignant process, given the risk of occult malignancy. Strength of recommendation: conditional recommendation based on low-quality evidence

17. Minimally invasive aerosolized approaches to peritoneal carcinomatosis require specialized equipment and expertise and have shown acceptable short-term oncologic outcomes, but there is a paucity of long-term data. Strength of recommendation: conditional recommendation based on low-quality evidence

2019 Updated recommendations

6. Biochemical testing should not be routinely performed in patients with appendiceal NETs before treatment, although in the setting of metastatic disease, it may be considered to establish a baseline for future disease monitoring. Strength of recommendation: strong recommendation based on moderate-quality evidence (previous recommendation stated routine biochemical testing)

10. Cross-sectional imaging with CT or MRI should be obtained at the time of diagnosis in patients with appendiceal epithelial neoplasms and routinely used for postoperative surveillance. Strength of recommendation: strong recommendation based on moderate-quality evidence (previously strong recommendation based on low-quality evidence)

2019 Excluded recommendations

1. Patients with appendiceal neoplasms should undergo a complete history and physical examination. Strength of recommendation: strong recommendation based on low-quality evidence

ASCRS = American Society of Colon and Rectal Surgeons; NET = traditional neuroendocrine tumor.

appendiceal neoplasms often provides inaccurate results, especially with mucinous neoplasms.$^{9-11}$ A final definitive diagnosis usually requires analysis of the entire specimen and should be reviewed before assessing the patient's candidacy for an oncologic right colectomy.

3. Interval appendectomy after complicated appendicitis is typically recommended in adult patients older than age 40 years and in those with imaging findings suggestive of a malignant process, given the risk of occult malignancy. Strength of recommendation: conditional recommendation based on low-quality evidence.

The low rate of recurrent appendicitis after initial nonsurgical management of complicated appendicitis supports the recently implemented strategy of omitting routine interval appendectomy. Arguments against routine interval appendectomy include cost, potential morbidity, complications associated with the procedure, low rate of recurrence after treatment with antibiotics (5%–18%), and a historically low incidence of appendiceal neoplasms in patients with acute appendicitis (1%–2%).$^{33}$⁻$^{39}$ However, reports on the incidence of appendiceal neoplasms were largely from retrospective studies with significant heterogeneity, lack of axial imaging, and a substantial number of pediatric patients.$^{7}$,$^{36}$,$^{40}$ Several recent reports have suggested an increased incidence of appendiceal neoplasms in adult patients with acute appendicitis (20%–29%).$^{41}$⁻$^{43}$ Reported risk factors for appendiceal neoplasms after acute appendicitis include complicated appendicitis, age older than 40 years, and radiologic appearance of an inflammatory mass.$^{35}$,$^{43}$⁻$^{45}$

A retrospective study of 402 patients who underwent an interval appendectomy for complicated appendicitis showed an overall neoplasm rate of 9%. Patients with an appendiceal neoplasm were significantly older (56.6 vs 45.1 years, $p < 0.01$).$^{43}$ No patients younger than 30 years

had a neoplasm. The rate of appendiceal neoplasms was 11% in patients 30 years or older, 16% in those older than 50 years, and 43% in those older than 80 years.$^{43}$ A systematic review and meta-analysis of 8 studies showed a pooled prevalence of neoplasms after interval appendectomy of 11% (95% CI, 7-15; $I^2 = 37.5\%$, $p = 0.13$).$^{45}$ Among these patients, appendiceal mucinous neoplasms occurred in 43% (95% CI, 19-68), adenocarcinoma in 29% (95% CI, 6-51), appendiceal neuroendocrine neoplasm in 21% (95% CI, 6-36), GCA in 13% (95% CI, 2-28), and adenoma or serrated lesions in 20% (95% CI, 0-41) of cases.$^{45}$

The decision-making for performing an interval appendectomy after initial nonoperative management of presumed appendicitis is complex. Surgeons must consider the risk for occult appendiceal neoplasm, and at a minimum, patients should be informed of this risk and educated on their potential pathological diagnoses.

APPENDICEAL NETS

4. Preoperative assessment of patients with appendiceal NETs should include physical examination, colonoscopy, and CT or MRI of the chest, abdomen, and pelvis. Strength of recommendation: strong recommendation based on low-quality evidence.

Preoperative evaluation of patients with appendiceal NETs should include a history and physical examination with an associated review of systems. Although rare with appendiceal NETs, positive review of systems for cardiac syndrome features (eg, flushing, diarrhea) may indicate the presence of metastatic disease or synchronous lesions, potentially altering the therapeutic approach.$^{46,47}$ In comparison to small-bowel NETs, appendiceal NETs rarely have synchronous lesions or distant metastatic disease.$^{48}$

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A preoperative colonoscopy is indicated, given the association with synchronous, non-NET lesions that may be present up to 22% of the time.$^{49-53}$ Additional findings on screening colonoscopy also may inform surgical planning.

Additionally, preoperative imaging is important for adequate staging, mainly to rule out distant metastatic disease. CT and ultrasound imaging have been associated with inferior results in general compared with intraoperative findings and final surgical pathology results, with accuracy rates of 40% and 25.5%, respectively.$^{54}$ MRI has been associated with improved staging, operative planning, and outcomes.$^{47,55}$ NET-specific imaging is discussed in the next statement.

5. NET-specific imaging should be considered in patients with lesions >2 cm, symptoms of carcinoid syndrome, and findings indeterminate for metastatic disease on other imaging studies. Strength of recommendation: conditional recommendation based on moderate-quality evidence.

Appendiceal NETs typically express somatostatin receptors, making imaging studies using radiolabeled somatostatin analogs, including $^{68}$Ga-DOTATATE, highly useful in disease detection. Previously, somatostatin receptor scintigraphy (SSRS) was the mainstay of NET imaging, but it has been largely replaced by $^{68}$Ga-DOTA PET/CT scans.$^{56}$ $^{68}$Ga-DOTA PET/CT is more sensitive for the detection of well-differentiated NET tumors than SSRS and may also detect occult lesions.$^{57,58}$ In a prospective study of 101 consecutive patients with NETs, of whom 75% had gastroenteropancreatic NETs,$^{68}$Ga-DOTA PET/CT identified additional metastatic lesions in 48% of patients (37/77) with known metastatic disease and in 21% of patients (5/24) without known metastatic disease compared with prior cross-sectional imaging with CT/MR and/or indium-111 pentetroteide.$^{59}$ In addition, a previously occult primary tumor was detected in 23% of patients (3/13) with primary unknown metastatic disease. Treatment plans were modified in 35% of patients (36/101) based on the results of the $^{68}$Ga-DOTA PET/CT.$^{59}$ In addition to higher diagnostic accuracy, $^{68}$Ga-DOTA PET/CT scans also require less time and a lower dose of radiation per scan compared with SSRS.

$^{68}$Ga-DOTA PET/CT has also been shown to be superior to FDG F18 PET/CT in the detection of gastro-enteropancreatic NETs.$^{60-62}$ Given the high sensitivity of $^{68}$Ga-DOTA PET/CT, this additional information may also help guide surgical management and the selection of somatostatin receptor antagonists in the setting of locore-gionally advanced and metastatic disease.$^{63,64}$ However, the utility of DOTA scans should be balanced with the cost of the study.$^{68}$Ga-DOTA PET/CT scans should predominately be considered in cases where there is higher potential for metastatic disease, including lesions >2 cm,

symptoms of carcinoid syndrome, and findings indeterminate for metastatic disease on other imaging studies.$^{63,64}$

Appendiceal NETs are generally not biochemically active unless there is a significant burden of hepatic metastases or there is direct systemic venous drainage leading to first-pass metabolism. Serum CgA and 24-hour urine 5-hydroxyindoleacetic acid (5-HIAA) are the most common metabolites produced by NETs; however, given their poor sensitivity and specificity in detecting early metastatic disease, these markers should not be routinely checked at initial diagnosis of appendiceal NETs.$^{65,66}$ Baseline values may be selectively performed in patients with radiographic evidence of metastatic disease, mainly for disease monitoring and assessment of treatment response.$^{67}$ Although mainly investigational, a multianalyte liquid biopsy of NET gene expression in blood recently showed increased diagnostic utility of early metastatic disease in GI NETs compared with CgA.$^{68-70}$

7. Extent of surgical resection of appendiceal NETs is determined by tumor size and histologic features. Strength of recommendation: strong recommendation based on low-quality evidence.

For nonmetastatic NETs confined to the appendix, treatment is generally based on size and histopathology of the primary tumor. Tumors of size >2 cm warrant a right hemicolectomy because nodal metastases are present in up to 40% of patients.$^{71-74}$ However, controversy remains in the surgical management of appendiceal NETs measuring 1 to 2 cm in size.$^{71,72,75}$ A large series of 435 patients showed that a cutoff tumor size >1.5 cm was independently related to nodal metastases.$^{76}$ In addition to size, tumor location at the base of the appendix, grading G2, and mesoappendiceal or lymphovascular invasion are also associated with nodal invasion.$^{47,77,78}$ Lymphovascular invasion has also been shown to be an independent risk factor for metastasis in patients with tumors <2 cm.$^{77,79,80}$ Additional unfavorable findings on histology include mesoappendiceal invasion >3 mm, advanced grade consisting of elevated mitotic index (more than 2 mitoses per high-power field), GCC histology, and Ki-67 index of more than 3% (Fig. 2).$^{73,77,81}$ Decision-making for right hemicolectomy in small- and intermediate-sized appendiceal NETs should be made on an individual basis, with consideration given to historic features and patient comorbidities and preferences, in a multidisciplinary setting.$^{77}$ Although the majority of appendiceal NETs occur at the tip of the appendix,

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patients with tumors present at the base of the appendix or those who undergone resection with a positive margin should typically undergo right hemicolectomy with regional lymphadenectomy.$^{82}$ Lesions <1 cm in diameter and without unfavorable features are adequately treated with an appendectomy and removal of the entire mesoappendix. Long-term disease-free survival in these patients is 100%.$^{83-86}$

8. Surveillance after resection of appendiceal NETs with curative intent should selectively involve physical examination, serial biochemical testing, and imaging of the chest, abdomen, and pelvis using either CT or MRI. Strength of recommendation: conditional recommendation based on low-quality evidence.

Surveillance after curative intent resection of appendiceal NETs depends on tumor size and histologic features. Overall and disease-free 5-year survival rates are very high, ranging from 85% to 95%,$^{80-89}$ and the overall risk of metastases is approximately 10%.$^{9,91}$ Small (<1 cm) lesions with favorable histologic features may not need surveillance. For lesions >2 cm or those with more aggressive histopathologic features, surveillance should typically include an updated history and physical examination, cross-sectional imaging, and colonoscopy. Typical intervals between surveillance evaluations are every 6 to 12 months for a total of 5 to 10 years,$^{92}$ depending on tumor

grade and stage, as well as the patient's clinical course.$^{91}$ Given that many NETs are removed during appendectomy for appendicitis,$^{47}$ patients should undergo colonoscopy after removal to rule out synchronous lesions. If a colonoscopy was performed before appendectomy, standard guidelines should be used during follow-up.

Appendiceal NETs are generally not biochemically active unless there is a significant burden of hepatic metastases or they have direct systemic venous drainage leading to first-pass metabolism, in which case the serum tumor markers CgA and 5-HIAA may help detect disease recurrence and response to therapy. In one meta-analysis including all types of GI NETs, CgA showed a sensitivity and specificity for disease progression or recurrence of 46% to 100% and 68% to 90%, respectively.$^{93}$ CgA and urine 5-HIAA levels are more sensible in those cases where the initial values were elevated. However, because of the nonspecific nature of these biomarkers, correlation with imaging studies is recommended.$^{94}$

Currently, there are insufficient data to support the routine use of NET-specific imaging modalities for routine surveillance, although they may be beneficial in confirming recurrent disease discovered on CT or MRI.$^{68,95,96}$ Ga-DOTA imaging is useful for restaging when there is clinical or biochemical evidence of disease recurrence or progression despite negative conventional imaging.$^{77}$

||ENETS|UICC/AJCC|ENETS|UICC/AJCC|ENETS|UICC/AJCC| |---|---|---|---|---|---|---| |Size|<1 cm|≤1 cm|1-2 cm|1-2 cm|>2 cm|2-4 cm| |T class|T1|T1a|T2|T1b|T3|T2 (or >)| |Infiltration of mesoappendix or serosa|0|-|<3 mm**|-|>3 mm**|-| |||||||| |||||||| |||||||| |||||||| |||||||| |||||||| |||||||| |||||||| |||||||| |||||||| |||||||| |||||||| |||||||| |||||||| |||||||| |||||||| ||<st||||||

FIGURE 2. Therapeutic algorithm for small appendiceal NET. AJCC = American Joint Committee on Cancer; ENET = European Neuroendocrine Tumor Society; G2 = grade 2 tumor (Ki-67 3%-20%); L1 = lymphatic invasion; NET = neuroendocrine tumor; UICC = Union for International Cancer Control; V1 = vascular invasion.

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APPENDICEAL MUCINOUS NEOPLASM AND ADENOCARCINOMA

9. CEA, CA 19-9, and CA-125 should typically be assessed on diagnosis of appendiceal epithelial neoplasms and routinely surveyed after resection. Strength of recommendation: conditional recommendation based on low-quality evidence.

The serum tumor markers CEA, CA 19-9, and CA-125 are frequently obtained on diagnosis of appendiceal mucious neoplasms and routinely monitored to assess disease remission or progression.$^{98}$ Although their individual predictability of disease recurrence has not been well characterized, combining tumor markers with imaging at baseline, during chemotherapy, and postoperatively has been useful in evaluating response to therapy and monitoring for disease recurrence. In the setting of mucinous adenocarcinosa of the appendix, a normal baseline CA-125 has been shown to correlate with achieving complete cytoreduction.$^{99}$ Elevated baseline CA19-9 has also been described as an independent predictor of worse progression-free survival and can be useful to diagnose disease recurrence after cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC).$^{99-101}$

The ultrasound HIPEC collaborative demonstrated worse progression-free survival in patients with elevated preoperative CA19-9 and worse overall survival in patients with mucinous adenocarcinoma and elevated CEA after CRS and HIPEC.$^{102}$ However, surveillance cross-sectional imaging is more sensitive for detecting peritoneal disease recurrence than tumor markers alone.$^{103}$ Despite many investigational attempts to use molecular profiling and tumor markers to distinguish LAMNs versus HAMNs, the most important diagnostic component is having an experienced pathologist who is familiar with this disease process review the pathology.$^{104-107}$

The sensitivity of cell-free circulating tumor DNA (ctDNA) in patients with appendiceal neoplasms has been reported as lower compared with other metastatic GI tumors.$^{108}$ However, the presence of ctDNA in both plasma and peritoneal fluid has been shown to be associated with systemic and peritoneal recurrence.$^{109}$

CT of the chest, abdomen, and pelvis is the most common imaging modality used to evaluate the primary tumor and assess for metastatic disease. The addition of a PET scan has not been shown to improve staging or significantly change management.$^{110}$ MRI can detect

extraluminal mucin and has also been shown to be superior to CT in the detection of peritoneal disease using a combination of diffusion-weighted imaging and gadolinium-enhanced sequences.$^{111}$ In small noncomparison studies, MRI has proven useful in predicting preoperative PCI and may be used in postoperative surveillance after CRS and HIPEC.$^{98,106}$ Unfortunately, cross-sectional imaging is inaccurate for obtaining a preoperative diagnosis and often will miss peritoneal disease. When a peritoneal disease is seen on imaging, several scoring systems have been developed to predict the likelihood of obtaining complete cytoreduction.$^{112}$ Although some have proposed using the 2010 WHO pathologic classification as a framework to report imaging findings in patients with appendiceal neoplasms, no structured imaging reporting systems are routinely used in this patient population.$^{113}$

Patients with LAMNs and HAMNs who undergo a margin-negative appendectomy with disease confined to the appendix rarely develop pseudomyxoma peritonei; therefore, frequent postoperative imaging for extended intervals is typical of minimal benefit.$^{8,114-116}$ Postoperative surveillance must be individualized according to tumor and patient characteristics. Patients with high-grade tumors or who undergo right hemicolectomy because of a locally advanced or perforated tumor, who have intermediate surgical margins, or who had lymphatic or peritoneal disease should typically undergo CT or MRI every 6 months for the first 3 years and yearly thereafter for 5 to 10 years. In patients with acellular or low-grade peritoneal disease who have undergone CRS and HIPEC, CT or MRI of the abdomen and pelvis is recommended at 3 to 6 months postoperatively (baseline), then every 6 to 12 months with tumor markers during the first 3 years and annual surveillance thereafter.$^{116-120}$

11. Routine peritoneal cytology is not recommended in patients with appendical tumors. Strength of recommendation: conditional recommendation based on low-quality evidence.

Although positive peritoneal cytology has varying degrees of utility in patients with pancreatic, gastric, or ovarian malignancies, the use of cytology in patients with appendiceal neoplasms remains unknown.$^{121-123}$ Some insight may be gained from extrapolation of studies on colorectal cancer with peritoneal spread. Positive peritoneal cytology occurs in 23.5% of treated patients and correlates with overall survival (19 vs 44 months for negative peritoneal cytology; $p = 0.01)$.$^{124}$ Another study of 205 patients with colorectal cancer undergoing CRS and HIPEC also showed that positive peritoneal cytology was independently associated with worse progression-free survival.$^{125}$ Neither of these studies performed a subgroup analysis for patients with appendiceal malignancies or evaluated its role in the decision to perform HIPEC.

GAERTNER ET AL: MANAGEMENT OF APPENDICEAL NEOPLASMS

During the past decade, various liquid biopsy techniques have emerged as viable alternatives to the analysis of traditional tissue biopsy samples. To date, the majority of research in the area of liquid biopsies has focused on blood-based biomarkers, predominantly using plasma-derived ctDNA.$^{126}$ However, ctDNA can also be obtained from various nonblood sources, including urine, cerebrospinal fluid, and pleural or peritoneal fluid. A study that longitudinally assessed peritoneal cytology and plasma and peritoneal ctDNA in 11 patients with KRAS-mutated colorectal and appendiceal cancer who were at risk or with established peritoneal involvement before and after HIPEC found that 2 of 7 patients with proven carcinomatosis had positive peritoneal cytology. Patients with positive plasma ctDNA had systemic relapse, and those with negative peritoneal ctDNA after CRS and HIPEC did not present peritoneal relapse. The authors concluded that treatment with CRS and HIPEC does not always neutralize ctDNA in peritoneal fluid, and its persistence after treatment may predict disease recurrence.$^{111}$

Although peritoneal ctDNA in patients with appendiceal neoplasms may play a complementary role for the prediction of peritoneal dissemination, future prospective and comparative studies are needed before incorporating peritoneal ctDNA in the diagnostic and treatment algorithms of patients with appendiceal neoplasms.

12. Patients with LAMNs with negative margins and no evidence of perforation or peritoneal involvement are safely treated with appendixomy alone. Strength of recommendation: strong recommendation based on moderate-quality evidence.

In contemporary observational studies, oncologic outcomes after appendectomy, including the entire mesoappendix for LAMNs without perforation or peritoneal involvement, have reported low recurrence rates, consistent with the indolent behavior of these neoplasms.$^{127-132}$ Appropriate initial surgical management is critical because iatrogenic rupture of the appendix can convert the situation from localized to disseminated. If an unruptured LAMN cannot be safely resected laparoscopically, conversion to an open operation is recommended.$^{127,128}$ In a review of 217 patients with localized LAMNs, recurrence was 15% in patients with perforation versus 0% in those without ($p < 0.001$).$^{128}$ Limited published data suggest that a microscopically positive resection margin after appendectomy for nonperforated LAMN does not predict disease recurrence and therefore does not warrant further treatment.$^{129,130}$ After surgical resection of localized LAMN without perforation or spillage, postreatment surveillance may not be necessary.$^{115,128}$ A study reviewing 114 patients across 10 years from an 11-hospital network found that surveillance (with office visit, CT, MRI, colonoscopy, or tumor markers) was performed in 34% of patients, but none of these patients experienced tumor recurrence at a mean follow-up of 4.7 years.$^{114}$

HAMNs without perforation or peritoneal involvement and a negative microscopic margin, when found incidentally in an appendectomy specimen, can generally be treated with appendectomy alone. However, care should be taken to exclude the presence of associated invasive adenocarcinoma, including a comprehensive histologic evaluation of the entire surgical specimen by an expert pathologist. Given the rarity and paucity of data on HAMNs, there should be a low threshold to review and discuss these cases in a multidisciplinary setting.

13. Patients with nonmetastatic adenocarcinoma of the appendix should undergo right hemicolectomy. However, in the setting of peritoneal spread, right hemicolectomy typically does not confer a survival benefit. Strength of recommendation: strong recommendation based on low-quality evidence.

In patients with appendiceal adenocarcinoma, the rate of metastatic disease to regional lymph nodes ranges from 20% to 67%, with positive nodes more likely in the non-mucinous subtype.$^{131-137}$ Because of this risk, the majority of patients with adenocarcinoma confined to the appen-dix should be treated with oncologic right hemicolec-tomy. Formal resection of the nodal basin allows for more complete staging, may have a therapeutic benefit, and can further guide the need for adjuvant systemic chemother-apy.$^{137-140}$ The recommendation for oncologic right col-ectomy also includes patients with appendiceal GCAs or tumors characterized by a mixture of histologic features of both neuroendocrine and epithelial adenocarcinoma.$^{141-143}$

In the setting of peritoneal metastases, routine right hemicoectomy to remove clinically normal lymph nodes is not recommended. Several single-institution and retrospective observational studies have failed to demonstrate a survival benefit to right hemicoectomy versus appendectomy alone in patients undergoing CRS and HIPEC.$^{144-147}$ A Surveillance, Epidemiology, and End Results database study found that right colectomy was not associated with survival after adjusting for age, sex, T stage, metastatic disease, and histologic grade. Interestingly, median survival for patients having appendectomy compared with right hemicolectomy was similar, even in node-positive patients.$^{147}$ Despite these reservations, it should be noted that a right hemicolectomy is sometimes necessary to achieve a complete cytoreduction of peritoneal disease originating from the appendix.

14. CRS is indicated in select patients with appendiceal neoplasms and evidence of peritoneal involvement. Strength of recommendation: strong recommendation based on moderate-quality evidence.

Surgical resection remains the first-line treatment for patients with appendiceal neoplasms with peritoneal metastases. The goal of CRS is the eradication of all macroscopic diseases to be followed by intraperitoneal

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chemotherapy, such as HIPEC (see subsequent recommendation). Typically, CRS entails peritonectomy of all involved surfaces, which may include the diaphragms, pelvis, bowel surface, complete omentectomy, and additional resections, depending on tumor involvement.$^{148-150}$ Even when the omentum appears macroscopically normal, omentectomy is typically recommended given the high risk of microscopic disease and low morbidity. Individualized decisions regarding CRS with or without HIPEC should be undertaken by a multidisciplinary team, preferably at experienced centers.$^{151-155}$ Proper patient selection is crucial in treating patients with peritoneal involvement from appendiceal neoplasms.$^{156}$ Findings on cross-sectional imaging may help determine resectability and guide the selection of suitable candidates for cytoreduction.$^{157,158}$ Diagnostic laparoscopy may also be used to estimate the likelihood of complete cytoreduction or to obtain tissue if other techniques such as CT-guided biopsy are not feasible to initially obtain a diagnosis. During CRS, the burden of peritoneal disease is quantified using the PCI or the Peritoneal Surface Disease Severity Score.$^{158-160}$ The PCI is calculated by dividing the abdomen into 13 regions, with each region receiving a score of 0 to 3 based on the size of the implants. Therefore, scores can range from 0 to 39. In contemporary, large cohorts evaluating clinical and pathologic factors, completeness of cytoreduction, whether performed open or laparoscopically, is consistently an independent predictor of outcome.$^{150-152,161-164}$ Even after grossly complete cytoreduction, peritoneal recurrences are common, ranging from 7% to 37%. Repeat cytoreduction can be considered on a case-by-case basis and depends on tumor histology, disease-free interval, burden of disease recurrence, and patient performance status.$^{165-169}$

Women with a peritoneal spread often experience ovarian involvement, even with macroscopically normal ovaries. Metastatic ovarian tumors may grow rapidly and are typically resistant to systemic chemotherapy.$^{154,155}$ A retrospective study of 258 female patients with 1 or more remaining ovaries who underwent CRS and HIPEC for colorectal and appendiceal tumors found that 141 patients (55%) had ovarian tumor involvement. Of 40 patients with 1 macroscopic ovarian metastasis, microscopic involvement of the contralateral ovary was found in 18 patients (45%). Of 141 patients in whom both ovaries were macroscopically normal, 24 (17%) had microscopic ovarian involvement.$^{170}$ Given the risk of occult ovarian metastases in this patient population, bilateral salpingoophorectomy should be strongly considered (especially for postmenopausal women), and patients should be appropriately counseled preoperatively.$^{171,172}$

The management of patients with limited peritoneal involvement of cellular or acellular mucin in the setting of LAMN remains controversial, particularly when it is isolated to the right lower quadrant.$^{173}$ Importantly, cellular versus acellular mucin can only be established after

surgery (appendectomy or biopsy of a mucinous peritoneal implant), and the inability to rely on an intraoperative frozen section plays a pivotal role in this decision-making. Appendectomy with cytoreduction of the periappendiceal peritoneum in these cases has been associated with very low peritoneal recurrence rates between 0% and 5% and with similar outcomes comparing cytoreduction versus HIPEC.$^{8,115,173}$ Conversely, LAMNs associated with cellular mucin deposits are associated with a higher risk of subsequent peritoneal involvement (33%–78%); these patients should be surveyed closely and considered for cytoreduction and HIPEC.$^{116,174,175}$

15. In patients with appendiceal epithelial neoplasms, intraperitoneal chemotherapy after CRS compared to CRS alone may reduce peritoneal disease recurrence, although its impact on overall survival is not established and has been associated with increased costs and toxicity. Strength of recommendation: strong recommendation based on moderate-quality evidence.

After complete resection of all gross peritoneal disease, patients with appendiceal neoplasms may be treated with intraperitoneal chemotherapy. Most commonly, this is performed concurrently with CRS through the delivery of HIPEC. A large randomized controlled trial for peritoneal carcinomatosis of colorectal origin demonstrated a doubling of survival for CRS and HIPEC compared with systemic chemotherapy alone (median overall survival 22.3 vs 12.6 months, $p = 0.032$).$^{176}$ Although only 18 of these 105 patients with peritoneal carcinomatosis were of appendiceal origin, additional long-term follow-up demonstrated a median disease-specific survival of 12.6 months in the control arm and 22.2 months in the HIPEC arm ($p = 0.028$) and a 5-year survival of 45% for those patients for whom a complete cytoreduction could be achieved.$^{177}$ Multiple large retrospective and prospective phase II studies, including patients with both low-grade and high-grade peritoneal disease, have demonstrated improved long-term patient survival, decreased tumor recurrence, longer time to disease progression, and less frequent repeat operative interventions in patients who undergo CRS plus HIPEC compared with CRS alone or palliative systemic chemotherapy.$^{16-18,178-186}$ Although retrospective, noncomparative data on HIPEC with low-grade peritoneal disease has shown improved short-term oncologic-specific outcomes compared to patients with high-grade peritoneal disease, prospective data do not exist. A 2012 observational study including 2,298 patients reported superior progression-free survival associated with HIPEC after CRS (HR 0.65; $p = 0.03$) for metastatic appendiceal mucinous neoplasm, but there was no overall survival difference in their multivariate analysis.$^{16}$ The median overall survival was 16.3 years, and the median progression-free survival was 8.2 years.$^{16}$

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The multicenter French open-label (PRODIGE 7) trial randomly assigned 265 patients with metastatic colorectal (not appendiceal) cancer (with PCI ≤25) undergoing CRS to either HIPEC (oxaliplatin) or no HIPEC.$^{187}$ The majority of patients had received systemic chemotherapy and had previous resection of the primary tumor. At a median follow-up of 64 months, overall survival and recurrence-free survival were similar (42 vs 41 months, HR 1.00, p = 0.99; and HR 0.91, p = 0.43, respectively), and grade 3 or worse adverse events at 30 days and 60 days were significantly associated with HIPEC (42% vs 32%, p = 0.083; and 26% vs 15%, p = 0.035, respectively). No such multicenter randomized clinical trial for appendiceal adenocarcinoma currently exists.

Mitomycin and oxaliplatin are the most common drugs used during HIPEC and have shown similar disease-free and overall survival rates, as well as toxicity, with a higher incidence of major complications and cost with oxaliplatin.$^{188-190}$ Both open and closed techniques for delivery of HIPEC have proven to be safe with no clear advantages regarding operative morbidity, postoperative complications, or oncologic-specific outcomes.$^{191}$ In addition, there is no clear consensus regarding the ideal duration or temperature of HIPEC.

Aside from HIPEC, other methods for delivering intraperitoneal chemotherapy include early postoperative intraperitoneal chemotherapy (EPIC) or delayed postoperative approaches.$^{19,192-199}$ Generally, similar results are obtained among the various approaches, and few head-to-head comparisons exist. A retrospective study of 93 patients in Norway compared EPIC and HIPEC after complete cytoreduction and showed no difference in 10-year overall survival and disease-free survival.$^{19}$ All 93 patients with colorectal or high-grade appendiceal carcinomato-sis were treated with CRS and HIPEC + EPIC or HIPEC alone. Three-year overall and recurrence-free survival rates were 50% and 21% for HIPEC + EPIC and 46% and 6% for HIPEC alone ($p = 0.72$ and $p = 0.89$, respectively). HIPEC + EPIC patients experienced more grade III/IV complications (43% vs 20%, $p = 0.01$).$^{19}$

16. Systemic chemotherapy may improve survival in patients with metastatic and lymph node-positive disease, HAMNs, and adenocarcinoma with peritoneal metastases. Routine use of systemic chemotherapy for LAMNs or well-differentiated mucinous adenocarcinoma with peritoneal spread is not recommended. Strength of recommendation: strong recommendation based on low-quality evidence.

The role of systemic chemotherapy and the optimal chemotherapeutic drug regimen for the treatment of metastatic mucinous and nonmucinous appendiceal adenocarcinoma, signet-ring cell carcinoma, or high-grade GCA continues to be investigated because of the rarity and heterogeneity of these neoplasms. Although there is

no level I evidence, a multimodal approach using systemic chemotherapy, such as that commonly used for metastatic colorectal cancer, is typically recommended for patients with high-grade and metastatic disease.$^{200,201}$ One study of 109 patients showed no discernible benefit in progression-free survival (13.6 vs 13.6 months, p = 0.59) or overall survival (34.6 vs 29.3 months, p = 0.98) with the use of perioperative systemic chemotherapy compared with CRS and HIPEC alone.$^{202}$ The use of perioperative systemic chemotherapy showed improved progression-free survival in patients with incomplete cytoreductions (8.6 vs 4.8 months, p = 0.05) or had signet-ring cells (10.9 vs 4.8 months, p = 0.06). Another study of 103 patients reported that the median overall survival for non-low-grade and well-differentiated tumor patients who received adjuvant chemotherapy after complete cytoreduction was 9.03 years compared with 2.88 years for patients who did not receive adjuvant chemotherapy (p = 0.02).$^{135}$ The authors also noted that systemic chemotherapy for low-grade cancers was not beneficial in terms of overall survival.

Although the timing of perioperative systemic chemotherapy has shown conflicting results, there are several potential advantages of preoperative chemotherapy, including the ability to assess disease response and patient tolerance, potentially downstage tumors, and allow for as-yet-undeclared distant metastatic disease to appear on imaging and possibly preclude CRS of questionable benefit.$^{46,203,204}$ A prospective study comparing preoperative systemic chemotherapy (n = 34) or not (n = 24) in patients with peritoneal carcinomatosis of appendiceal origin showed a complete or near complete histological response in 29% of patients who received preoperative systemic chemotherapy. Patients receiving preoperative systemic chemotherapy had a lower PCI (p = 0.0003), required fewer visceral resections (2.7 vs 4.4), and achieved complete cytoreduction more frequently compared to patients with no preoperative chemotherapy. The incidence of perioperative complications (p = 0.16) and overall survival were not significantly different between the 2 groups (37.2 vs 50.5 months; p = 0.56). However, among the patients who received neoadjuvant chemotherapy, survival was significantly better for patients who experienced a histological complete or near complete response (p = 0.033).$^{205}$

LAMN with or without peritoneal spread is considered an indent process, which generally shows minimal to no response to systemic chemotherapy. Thus, CRS with or without HIPEC is the mainstay of treatment when possible.$^{202-204,206}$ For patients with unresectable LAMN or recurrent disease that is not amenable to CRS and HIPEC, systemic chemotherapy may be used, though minimal benefit has been found in this subgroup of patients.$^{201-204,207}$

17. Minimally invasive aerosolized approaches to peritoneal carcinomatosis require specialized equipment and expertise and have shown acceptable short-term

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oncologic outcomes, but there is a paucity of long-term data. Strength of recommendation: conditional recommendation based on low-quality evidence.

Pressurized intraperitoneal aerosol chemotherapy (PIPAC) has been developed as a potential alternative surgical technique in the palliative setting for peritoneal metastases that are not amendable to CRS-HIPEC. PIPAC uses a minimally invasive approach with repeated administration of aerosolized chemotherapy with potential for enhanced pharmacokinetics.$^{208-211}$ The technique has shown a good safety profile and encouraging oncological results for primary and metastatic peritoneal malignancies.$^{212-215}$ However, PIPAC has been used in a heterogeneous group of peritoneal malignancies, and there are currently limited data on its utilization in patients with appendiceal neoplasms and peritoneal involvement.

A recent multi-institutional study of 77 consecutive patients with appendiceal peritoneal metastases who underwent 208 PIPAC procedures (45% had 3 or more procedures and the majority with oxaliplatin) showed a complete response in 11% and partial/stable response in 31%. Peritoneal cytology and PCI did not influence treatment response. For patients who underwent at least 3 PIPAC treatments, the overall survival was 22 months.$^{209}$

Clinical trials are currently underway examining the role of PIPAC in patients with unresectable appendical, colorectal, ovarian, uterne, and gastric cancers (NCT04329494).$^{210-222}$

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表 1
Evaluation	Description
Recommendation
Strong	Most individuals should receive the intervention. Formal decision aids are not likely to be needed to help individuals make decisions consistent with their values and preferences
Conditional	Different choices will be appropriate for individual patients consistent with their values and preferences. Use shared decision-making. Decision aids may be useful in helping patients make decisions consistent with their individual risks, values, and preferences
GRADE certainty ranking
High	The authors are confident that the true effect is similar to the estimated effect
Moderate	The authors believe that the true effect is probably close to the estimated effect
Low	The true effect might be markedly different from the estimated effect
Very low	The true effect is probably markedly different from the estimated effect

表 2
	Summary	Recommendation strength	GRADE quality of evidence
1	Colonoscopy should be performed in patients with confirmed or suspected appendiceal neoplasms	Strong	Low
2	Appendectomy should be performed if a grossly abnormal appendix is encountered during an unrelated abdominal operation	Strong	Low
3	Interval appendectomy after complicated appendicitis is typically recommended in adult patients older than 40 y and in those with imaging findings suggestive of a malignant process, given the risk of occult malignancy	Conditional	Low
4	Preoperative assessment of patients with appendiceal NETs should include physical examination, colos-noscopy, and CT or MRI of the chest, abdomen, and pelvis	Strong	Low
5	NET-specific imaging should be considered in patients with lesions >2 cm, symptoms of carcinoid syndrome, and findings indeterminate for metastatic disease in other imaging studies	Conditional	Moderate
6	Biochemical testing should not be routinely performed in patients with appendiceal NETs before treatment, although in the setting of metastatic disease, it may be considered to establish a baseline for future disease monitoring	Strong	Moderate
7	Extent of surgical resection of appendiceal NETs is determined by tumor size and histologic features	Strong	Low
8	Surveillance after resection of appendiceal NETs with curative intent should selectively involve physical examination, serial biochemical testing, and imaging of the chest, abdomen, and pelvis using either CT or MRI	Conditional	Low
9	CEA, CA 19-9, and CA-125 should typically be assessed on the diagnosis of appendiceal epithelial neoplasms and routinely surveyed after resection	Conditional	Low
10	Cross-sectional imaging with CT or MRI should be obtained at the time of diagnosis in patients with appendiceal epithelial appendiceal epithelina neoplasms and routinely used for postoperative surveillance	Strong	Moderate
11	Routine peritoneal cytology is not recommended in patients with appendiceal tumors	Conditional	Low
12	Patients with LAMNs with negative margins and no evidence of perforation or peritoneal involvement	Strong	Moderate
13	Patients with nonmetastatic adenocarcinoma of the appendix should undergo right hemicolectomy. However, in the setting of peritoneal spread, right hemicolectomy typically does not confer a survival benefit	Strong	Low
14	Cytoreductive surgery is indicated in select patients with appendiceal neoplasms and evidence of peritoneal involvement	Strong	Moderate
15	In patients with appendiceal epithelial neoplasms, intraperitoneal chemotherapy after cytoreductive surgery compared to cytoreductive surgery alone may reduce peritoneal disease recurrence, although its impact on overall survival is not established and has been associated with increased costs and toxicity	Strong	Moderate
16	Systemic chemotherapy may improve survival in patients with metastatic, lymph node positive, HAMNs, and adenocarcinoma with peritoneal metastases. Routine use of systemic chemotherapy for LAMNs or well-differentiated mucinous adenocarcinoma with peritoneal spread is not recommended	Strong	Low
17	Minimally invasive aerosolized approaches to peritoneal carcinosis require specialized equipment and expertise and have shown acceptable short-term oncologic outcomes, but there is a paucity of long-term data	Conditional	Low

表 3
	ENETS	UICC/AJCC	ENETS	UICC/AJCC	ENETS	UICC/AJCC
Size	<1 cm	≤1 cm	1-2 cm	1-2 cm	>2 cm	2-4 cm
T class	T1	T1a	T2	T1b	T3	T2 (or >)
Infiltration of mesoappendix or serosa	0	-	<3 mm**	-	>3 mm**	-
















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引用 / 出处

2025 ASCRS临床实践指南：阑尾肿瘤的管理. 2025.